The members of the Safety Critical Systems Club (SCSC) represent a wide range of complex and engineered systems. The role of many organisations is to specify, design, make and assure complex safety critical systems, as well as to operate these systems and learn from experience. These systems are developed for and operated within sectors including defence, nuclear power generation, oil and gas, transport (aviation, marine and rail), automobiles, health care and others. This position paper aims to: Exemplify how safety culture manifests itself in the process of specifying, designing, manufacturing, operating and assuring complex safety critical systems; Provide guidance on good practice that organisations with safety critical activities should aim to achieve; Draw out key methods that are of particular importance to organisations with safety critical activities. The paper does not aim to provide detailed guidance or worked examples. Further reading and references are offered. While the guidance in this paper may apply equally to all safety domains, it focuses on the safety of designing, manufacturing, assuring and operating complex safety critical systems.